
The Early Modern period reminded me of books by Mark Z. Danielewski. He has written several novels so far, and both used different approaches to designing the text's layout. I included images from the second book
Only Revolutions. Click on them to view larger images. The top image is one of the end pages. It's actually niether front nor back because you read the book from both ends. Each direction gives you a story from another perspective. The end page is just a playful layout of words forming O shapes that repeat through out the book. The words are reversed so that you can only read them in a mirror. I feel that Danielewski did this so that you see the forms as shapes rather than the specific ideas they represent.
The bottom image is from an early page. He choose to have the top left section of the left page (and top right section of the right page) be one person's story. The bottom sections are the other persons story. As you go through your narrators section gets smaller, allowing more room for the alternate perspective. The middle sections on the gutter include dates and historical references for that time in the story. Danielewski alternates between justifying text to the left or right, giving the over text body a wavy, free-flowing quality. He also choose to bold words for emphasis, and play with capitals and italics.
You can also see two circles on each page. they include both page numbers for each perspective. As you flip the pages you notice the two numbers orbit each other. It's pretty cool that Danielewski took this into account. You can watch as the two circles complete one full revolution with the larger circle.
All the O's throughout the book have been printed in color ink (either green or gold depending). I have yet to see any positive effect this has on the story. It just seems like a ridiculous expensive to me.

This is a great example of how to creatively solve the problem of having a multiple perspective book. You can use this layout to enhance the reader's experience. You could also try this approach to get more attention. This kind of book is just really engaging to any potential reader, but if done poorly it could really distract from the plot or be too confusing to navigate.
As soon as I can get my hands on a copy of
House of Leaves I will bring it in. It's just the kind of thing you really need to flip through to experience.